Cover art/illustration by Marc-Antony Piñón, for “Cell Metabolism.”
On the cover: Obesity results in adipose tissue inflammation, which plays an important role in many of the complications of obesity. On pp. 411–422 of this issue, Deng et al. report that adipocyte leptin secretion, which increases early in diet-induced obesity, stimulates adipose-resident T cells to secrete IFN-γ to upregulate the class II major histocompatibility complex (MHCII) in adipocytes. Mice lacking leptin or MHCII develop less adipose inflammation than wild-type mice upon developing obesity. The cover image illustrates the crosstalk between adipocytes and immune cells during diet-induced obesity that leads to adipose inflammation.